HRID1397007

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16217889

6-(Thiophen-3-yl)pyridine-2-carbaldehyde

C10H7NOS

$结构：COc1cc(/C=C2\SC(=O)NC2=O)nc(N2CCC(CN)CC2)n1$

HCID53251145

未命名化合物

PRODUCTS

生成物

$结构：COc1cc(/C=C2\SC(=O)NC2=O)nc(N2CCC(CNCc3cccc(-c4ccsc4)n3)CC2)n1$

HCID86672839

未命名化合物

PROCEDURE

实验过程

(Z)-5-((6-methoxy-2-(4-((((6-(thiophen-3-yl)pyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione was prepared using (Z)-5-((2-(4-(aminomethyl)piperidin-1-yl)-6-methoxypyrimidin-4-yl)methylene)thiazolidine-2,4-dione (Example 153), the general reductive amination procedure and 6-(thiophen-3-yl)picolinaldehyde (34.3 mg, 65 mg theoretical, 52.8%). LC-MS m/z 523 (M+1).