HRID1397009

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10606741

2-Fluoro-6-formylpyridine

C6H4FNO

$结构：COc1cc(/C=C2\SC(=O)NC2=O)nc(N2CCC(CN)CC2)n1$

HCID53251145

未命名化合物

PRODUCTS

生成物

$结构：COc1cc(/C=C2\SC(=O)NC2=O)nc(N2CCC(CNCc3cccc(F)n3)CC2)n1$

HCID66571263

未命名化合物

PROCEDURE

实验过程

(Z)-5-((2-(4-((((6-fluoropyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)-6-methoxypyrimidin-4-yl)methylene)thiazolidine-2,4-dione was prepared using (Z)-5-((2-(4-(aminomethyl)piperidin-1-yl)-6-methoxypyrimidin-4-yl)methylene)thiazolidine-2,4-dione (Example 153), the general reductive amination procedure and 6-fluoropicolinaldehyde (26.1 mg, 59 mg theoretical, 43.9%). LC-MS m/z 459 (M+1).