Boronic Acid → 6-(3-Furanyl)-2-pyridinecarboxaldehyde

HRID 1397012Notes

Reaction equation

HRID 1397012 reaction equation
B(O)O.Br[C:5]1[N:10]=[C:9]([CH:11]=[O:12])[CH:8]=[CH:7][CH:6]=1.[O:13]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14]1>>[O:13]1[CH:17]=[CH:16][C:15]([C:5]2[N:10]=[C:9]([CH:11]=[O:12])[CH:8]=[CH:7][CH:6]=2)=[CH:14]1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 2734358Furan-3-boronic acidHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 193617296-(3-Furanyl)-2-pyridinecarboxaldehyde

Procedure

6-(furan-3-yl)picolinaldehyde was prepared using the general boronic acid coupling procedure for 6-bromopicolinaldehyde and furan-3-ylboronic acid (65 mg, 93.2 mg theoretical, 69.8%). LC-MS m/z 174.2 (M+1).

Sources & evidence

ORD record
ord-264580271c7044edb86461a4de3698e0
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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