Boronic Acid → HCID 12075427, compound

HRID 1397014Notes

Reaction equation

HRID 1397014 reaction equation
B(O)O.Br[C:5]1[N:10]=[C:9]([CH:11]=[O:12])[CH:8]=[CH:7][CH:6]=1.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1>>[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[C:19]([C:5]2[N:10]=[C:9]([CH:11]=[O:12])[CH:8]=[CH:7][CH:6]=2)[CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 12075427HCID 12075427, compound

Procedure

6-(3-(trifluoromethyl)phenyl)picolinaldehyde was prepared using the general boronic acid coupling procedure for 6-bromopicolinaldehyde and (3-(trifluoromethyl)phenyl)boronic acid (115 mg, 135.1 mg theoretical, 85.1%). LC-MS m/z 252.2 (M+1).

Sources & evidence

ORD record
ord-dca05c297a944249aadbb8549f6772a5
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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