Boronic Acid → HCID 86672845, compound

HRID 1397021Notes

Reaction equation

HRID 1397021 reaction equation
B(O)O.Br[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8].[NH:13]1[C:17](B(O)O)=[CH:16][CH:15]=[N:14]1>>[NH:13]1[C:17]([C:5]2[N:12]=[CH:11][CH:10]=[CH:9][C:6]=2[CH:7]=[O:8])=[CH:16][CH:15]=[N:14]1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 47149512-BromonicotinaldehydeHCID 112519791H-Pyrazole-5-boronic acid

Product 1

HCID 86672845HCID 86672845, compound

Procedure

2-(1H-pyrazol-5-yl)nicotinaldehyde was prepared using the general boronic acid coupling procedure for 2-bromonicotinaldehyde and (1H-pyrazol-5-yl)boronic acid (60 mg, 93.2 mg theoretical, 64.4%). LC-MS m/z 174.2 (M+1).

Sources & evidence

ORD record
ord-168b6ffe932440ed80db211dc04249ee
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

Loading…