Boronic Acid → HCID 86672847, compound

HRID 1397023Notes

Reaction equation

HRID 1397023 reaction equation
B(O)O.Br[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8].[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1B(O)O>>[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8]

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27343872-(Trifluoromethyl)benzeneboronic acidHCID 47149512-Bromonicotinaldehyde

Product 1

HCID 86672847HCID 86672847, compound

Procedure

2-(2-(trifluoromethyl)phenyl)nicotinaldehyde was prepared using the general boronic acid coupling procedure for 2-bromonicotinaldehyde and (2-(trifluoromethyl)phenyl)boronic acid (40 mg, 93.2 mg theoretical, 42.9%). LC-MS m/z 252.2 (M+1).

Sources & evidence

ORD record
ord-93fafcd4658b4dd291460a2e4cbfc994
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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