Boronic Acid → HCID 82382590, compound

HRID 1397024Notes

Reaction equation

HRID 1397024 reaction equation
B(O)O.Br[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8].[F:13][C:14]([F:25])([F:24])[C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1>>[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[C:19]([C:5]2[N:12]=[CH:11][CH:10]=[CH:9][C:6]=2[CH:7]=[O:8])[CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 47149512-Bromonicotinaldehyde

Product 1

HCID 82382590HCID 82382590, compound

Procedure

2-(3-(trifluoromethyl)phenyl)nicotinaldehyde was prepared using the general boronic acid coupling procedure for 2-bromonicotinaldehyde and (3-(trifluoromethyl)phenyl)boronic acid (100 mg, 135.1 mg theoretical, 74%). LC-MS m/z 252.2 (M+1).

Sources & evidence

ORD record
ord-ca4306247c6a4046ae49539c3fce9640
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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