Boronic Acid → HCID 86672848, compound

HRID 1397025Notes

Reaction equation

HRID 1397025 reaction equation
B(O)O.Br[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8].[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1>>[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][C:18]([C:5]2[N:12]=[CH:11][CH:10]=[CH:9][C:6]=2[CH:7]=[O:8])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 47149512-Bromonicotinaldehyde

Product 1

HCID 86672848HCID 86672848, compound

Procedure

2-(4-(trifluoromethyl)phenyl)nicotinaldehyde was prepared using the general boronic acid coupling procedure for 2-bromonicotinaldehyde and (4-(trifluoromethyl)phenyl)boronic acid (93.8 mg, 135.1 mg theoretical, 69.4%). LC-MS m/z 252.2 (M+1).

Sources & evidence

ORD record
ord-009ef54745ba4574b95ca738629c8594
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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