Boronic Acid → HCID 86263259, compound

HRID 1397027Notes

Reaction equation

HRID 1397027 reaction equation
B(O)O.Br[C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][N:12]=1)[CH:8]=[O:9].[S:13]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14]1>>[S:13]1[CH:17]=[CH:16][C:15]([C:5]2[CH:6]=[C:7]([CH:10]=[CH:11][N:12]=2)[CH:8]=[O:9])=[CH:14]1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 581760Thiophene-3-boronic acidHCID 27629912-Bromo-4-pyridinecarboxaldehyde

Product 1

HCID 86263259HCID 86263259, compound

Procedure

2-(thiophen-3-yl)isonicotinaldehyde was prepared using the general boronic acid coupling procedure for 2-bromoisonicotinaldehyde and thiophen-3-ylboronic acid (89 mg, 101.8 mg theoretical, 87.4%). LC-MS m/z 190.2 (M+1).

Sources & evidence

ORD record
ord-f6f592ba8fab4adeb0ac543330959c1d
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

Loading…