Boronic Acid → HCID 86672851, compound

HRID 1397029Notes

Reaction equation

HRID 1397029 reaction equation
B(O)O.Br[C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][N:12]=1)[CH:8]=[O:9].[C:13]([O:17][C:18]([N:20]1[CH:24]=[CH:23][CH:22]=[C:21]1B(O)O)=[O:19])([CH3:16])([CH3:15])[CH3:14]>>[CH:8]([C:7]1[CH:10]=[CH:11][N:12]=[C:5]([C:21]2[N:20]([C:18]([O:17][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:19])[CH:24]=[CH:23][CH:22]=2)[CH:6]=1)=[O:9]

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27343211-(tert-Butoxycarbonyl)-2-pyrroleboronic AcidHCID 27629912-Bromo-4-pyridinecarboxaldehyde

Product 1

HCID 86672851HCID 86672851, compound

Procedure

tert-butyl 2-(4-formylpyridin-2-yl)-1H-pyrrole-1-carboxylate was prepared using the general boronic acid coupling procedure for 2-bromoisonicotinaldehyde and (1-(tert-butoxycarbonyl)-1H-pyrrol-2-yl)boronic acid (56 mg, 146.5 mg theoretical, 38.2%). LC-MS m/z 273.3 (M+1).

Sources & evidence

ORD record
ord-86475f58c6fc434fbf8d0141666482d9
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

Loading…