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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1397032Generated: November 3, 2026

Boronic Acid → 3-Fluoro-6-(3-thienyl)-2-pyridinecarboxaldehyde

https://huagongshe.com/reaction/1397032

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBoronic AcidHCID 61668—
ReactantThiophene-3-boronic acidHCID 581760—
Reactant6-Bromo-3-fluoropyridine-2-carbaldehydeHCID 16414238—
Product3-Fluoro-6-(3-thienyl)-2-pyridinecarboxaldehydeHCID 86672853—

Reaction Steps

3-fluoro-6-(thiophen-3-yl)picolinaldehyde was prepared using the general boronic acid coupling procedure for 6-bromo-3-fluoropicolinaldehyde and thiophen-3-ylboronic acid (80.5 mg, 101.5 mg theoretical, 79.3%). LC-MS m/z 208.2 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08901145B2
Source datasetuspto-grants-2014_12
ORD IDord-7935a1b4cf954cc2bd0e2a378124b41f
Source noteuspto-grants-2014_12