Boronic Acid → 4-(2-Furanyl)-2-thiophenecarboxaldehyde

HRID 1397037Notes

Reaction equation

HRID 1397037 reaction equation
B(O)O.Br[C:5]1[CH:6]=[C:7]([CH:10]=[O:11])[S:8][CH:9]=1.[O:12]1[CH:16]=[CH:15][CH:14]=[C:13]1B(O)O>>[O:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:5]1[CH:6]=[C:7]([CH:10]=[O:11])[S:8][CH:9]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 877924-Bromothiophene-2-carbaldehydeHCID 2734357Furan-2-boronic acid

Product 1

HCID 230048654-(2-Furanyl)-2-thiophenecarboxaldehyde

Procedure

4-(furan-2-yl)thiophene-2-carbaldehyde was prepared using the general boronic acid coupling procedure with 4-bromothiophene-2-carbaldehyde and furan-2-ylboronic acid (26 mg, 93 mg theoretical, 28.0%). LC-MS m/z 179 (M+1).

Sources & evidence

ORD record
ord-8f7cd8ddb80248a880c5ac1a9062d9d2
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

Loading…