Boronic Acid → HCID 86672856, compound

HRID 1397038Notes

Reaction equation

HRID 1397038 reaction equation
B(O)O.Br[C:5]1[N:10]=[C:9]([CH:11]=[O:12])[C:8]([F:13])=[CH:7][CH:6]=1.[O:14]1[CH:18]=[CH:17][CH:16]=[C:15]1B(O)O>>[F:13][C:8]1[C:9]([CH:11]=[O:12])=[N:10][C:5]([C:15]2[O:14][CH:18]=[CH:17][CH:16]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 2734357Furan-2-boronic acidHCID 164142386-Bromo-3-fluoropyridine-2-carbaldehyde

Product 1

HCID 86672856HCID 86672856, compound

Procedure

3-fluoro-6-(furan-2-yl)picolinaldehyde was prepared using the general boronic acid coupling procedure with 6-bromo-3-fluoropicolinaldehyde and furan-2-ylboronic acid (41 mg, 94 mg theoretical, 43.6%). LC-MS m/z 192 (M+1).

Sources & evidence

ORD record
ord-8e9021ed5efb439eb81ce17a1d488f68
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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