Boronic Acid → HCID 18471199, compound

HRID 1397039Notes

Reaction equation

HRID 1397039 reaction equation
B(O)O.Br[C:5]1[CH:6]=[CH:7][C:8]([F:13])=[C:9]([CH:12]=1)[CH:10]=[O:11].[S:14]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15]1>>[F:13][C:8]1[CH:7]=[CH:6][C:5]([C:16]2[CH:17]=[CH:18][S:14][CH:15]=2)=[CH:12][C:9]=1[CH:10]=[O:11]

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 581760Thiophene-3-boronic acidHCID 7363275-Bromo-2-fluorobenzaldehyde

Product 1

HCID 18471199HCID 18471199, compound

Procedure

2-fluoro-5-(thiophen-3-yl)benzaldehyde was prepared using the general boronic acid coupling procedure with 5-bromo-2-fluorobenzaldehyde and thiophen-3-ylboronic acid (27 mg, 102 mg theoretical, 26.5%). LC-MS m/z 207 (M+1).

Sources & evidence

ORD record
ord-ebaa6858f53f436eb636525d40f39778
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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