Boronic Acid → HCID 86672857, compound

HRID 1397040Notes

Reaction equation

HRID 1397040 reaction equation
B(O)O.Br[C:5]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[C:6]=1[CH:7]=[O:8].[S:14]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15]1>>[F:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:5]([C:16]2[CH:17]=[CH:18][S:14][CH:15]=2)[C:6]=1[CH:7]=[O:8]

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 581760Thiophene-3-boronic acidHCID 224739772-Bromo-6-fluorobenzaldehyde

Product 1

HCID 86672857HCID 86672857, compound

Procedure

2-fluoro-6-(thiophen-3-yl)benzaldehyde was prepared using the boronic acid coupling procedure with 2-bromo-6-fluorobenzaldehyde and thiophen-3-ylboronic acid (66 mg, 102 mg theoretical, 64.7%). LC-MS m/z 207 (M+1).

Sources & evidence

ORD record
ord-4fc2d15847054377afe310da0a88dfc4
Source dataset
uspto-grants-2014_12
Patent number
US08901145B2

Reaction notes

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