Succinic anhydride → HCID 86666523, compound

Participants

Reaction Steps

Compound 9 (4.0 g, 10.39 mmol), succinic anhydride (1.04 g, 10.39 mmol), and 4-di(methylamino)pyridine (1.90 g, 15.59 mmol) were dissolved in CHCl3 (30 mL) and stirred for 24 h. The solvent was evaporated in vacuo and the crude material was purified by silica gel chromatography (40-80% EtOAc in hexanes) to give the compound 10 (1.66 g, 51%). 1H NMR (400 MHz, CDCl3) δ 2.64 (t, J=5.8, 2H), 2.70 (t, J=5.8, 2H), 4.21 (d, J=6.2, 4H), 4.61 (d, J=6.2, 2H), 4.65 (d, J=6.2, 2H), 5.22-5.35 (m, 4H), 5.89 (m, 2H).

Provenance & Evidence