HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Benzyloxy-N-(2-(dimethylamino)ethyl)-N-methylacetamide | HCID 66973978 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | N-(2-(Dimethylamino)ethyl)-2-Hydroxy-N-methylacetamide | HCID 54488530 | — |
Reaction Steps
Crude HCl salt of 101 was mixed with 201.8 mg (0.1896 mmol) of palladium on charcoal (10%) in 15 mL of methanol. The mixture was subjected to hydrogen atmosphere at 50 psi on a Parr apparatus at room temperature. After overnight, another 200.9 mg of catalyst was needed. After overnight, reaction was completed and the insolubles was filtered off through glass fiber filter paper. The filtrate was concentrated to yield 254.6 mg (quant.) of product 102 as HCl salt: 1H NMR (400 MHz, CDCl3): δ 2.89 (s, 6H), 3.06 (s, 3H), 3.21 (t, J=6.6, 2H), 3.93 (t, J=6.6, 2H), 4.25 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901072B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-abe3ab045c924e32830dddca0b58c0d6 |
| Source note | uspto-grants-2014_12 |