Potassium Carbonate → HCID 66632536, compound

Participants

Reaction Steps

To a solution of 3-{4-Fluoro-2-[3-(2-hydroxy-1-nonylcarbamoyl-ethylcarbamoyl)-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl]-phenyl}-propionic acid methyl ester (14.86 mmol) in dichloromethane (200 ml), at −78° C. and under nitrogen atmosphere, DAST (3.93 mL, 29.72 mmol) was added and the resulting mixture was stirred at room temperature for 2.5 h. After this time, potassium carbonate (4.11 g, 29.72 mmol) was added and the solution was stirred for another hour. Then saturated solution of NaHCO3 (200 mL) was added and the mixture was extracted with ethyl acetate (200 mL). Then, it was washed with Brine (150 mL), and dried over MgSO4. Filtration and concentrated in vacuo yield the crude compound as thick oil.

Provenance & Evidence