3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → HCID 69950068, compound

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Reaction Steps

This compound was synthesized from (4-(4-cyclohexylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (70 mg, yield 32%). 1H NMR (400 MHz, MeOD) δ 8.50 (t, J=1.5 Hz, 1H), 8.29 (dt, J=7.8 Hz, 1.4 Hz, 1H), 7.98 (m, 1H), 7.67 (t, J=7.8 Hz, 1H), 7.05 (s, 1H), 3.90-3.86 (dt, J=11.8 Hz, 3.9 Hz, 2H), 3.65 (s, 2H), 3.55-3.49 (m, 2H), 2.69 (m, 1H), 2.35 (d, J=13.8 Hz, 2H), 2.04-1.96 (m, 4H), 1.76-1.73 (m, 2H), 1.39 (m, 6H). MS (ESI) m/z: Calculated for C25H27F3N4O3S: 520.18. found: 521.2 (M+H)+.

Provenance & Evidence