3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → HCID 69950265, compound

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Reaction Steps

This compound was synthesized from (4-(4-(pyridin-4-yl)thiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (60 mg, yield 38%): 1H NMR (400 MHz, DMSO-d6) δ 8.82 (t, J=6.3 Hz, 1H), 8.57 (d, J=5.8 Hz, 2H), 8.45 (s, 1H), 8.40 (s, 1H), 8.19 (d, J=7.9 Hz, 1H), 8.05 (d, J=7.9 Hz, 1H), 7.87 (d, J=5.8 Hz, 2H), 7.70 (t, J=7.8 Hz, 1H), 3.87-3.84 (dt, J=12.1 Hz, 3.4 Hz, 2H), 3.59-3.58 (d, J=6.1 Hz, 2H), 3.42 (m, 2H), 2.28-2.24 (d, J=13.4 Hz, 2H), 2.04-1.96 (m, 2H). MS (ESI) m/z: Calculated for C24H20F3N6O3S: 515.12. found: 516.0 (M+H)+.

Provenance & Evidence