(4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine → 3-Methoxy-N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

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Reaction Steps

This compound was synthesized from (4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine and 3-methoxy-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (70 mg, yield 46%): 1H NMR (400 MHz, CDCl3) δ 8.75 (t, J=6.3 Hz, 1H), 8.08 (s, 1H), 8.02 (s, 1H), 7.91 (d, J=7.0 Hz, 2H), 7.63 (m, 1H), 7.57 (m, 1H), 7.38-7.35 (m, 2H), 7.30-7.26 (m, 1H), 3.85 (s, 3H), 3.83 (m, 2H), 3.56 (d, J=6.5 Hz, 2H), 3.41-3.36 (m, 2H), 2.23 (d, J=13.5 Hz, 2H), 2.01-1.94 (m, 2H). MS (ESI) m/z: Calculated for C26H23F3N4O4S: 544.14. found: 545.2 (M+H)+.

Provenance & Evidence