反应详情

This compound was synthesized from (4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine and 3-ethyl-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (85 mg, yield 45%). 1H NMR (400 MHz, CDCl3) δ 8.29 (s, 1H), 8.05 (s, 1H), 7.89 (m, 2H), 7.80 (s, 1H), 7.52 (m, 2H), 7.37-7.29 (m, 3H), 4.00-3.94 (m, 2H), 3.89 (d, J=5.5 Hz, 2H), 3.78-3.72 (ddd, J=11.7 Hz, 7.8 Hz, 3.3 Hz, 2H), 2.69 (q, J=7.7 Hz, 2H), 2.36-2.30 (ddd, J=13.6 Hz, 6.5 Hz, 3.3 Hz, 2H), 2.08-2.02 (ddd, J=13.6 Hz, 7.7 Hz, 3.3 Hz, 2H), 1.23 (t, J=7.7 Hz, 3H). MS (ESI) m/z: Calculated for C27H25F3N4O3S: 542.16. found: 543.2 (M+H)+.