HCID 19417527, compound → HCID 69950069, compound

Participants

Reaction Steps

This compound was synthesized from (4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine and 2-cyanocyclopropanecarboxylic acid as described in example 8 step 6 (90 mg, yield 29%): 1H NMR (400 MHz, CDCl3) δ 7.92 (m, 2H), 7.52-7.46 (m, 3H), 7.41-7.37 (m, 1H), 6.72 (t, J=5.3 Hz, 1H), 3.92-3.86 (m, 2H), 3.75-3.68 (m, 4H), 2.30-2.22 (dddd, J=13.2 Hz, 9.8 Hz, 6.5 Hz, 3.4 Hz, 2H), 1.99-1.89 (m, 4H), 1.52-1.47 (ddd, J=9.1 Hz, 5.8 Hz, 4.6 Hz, 1H), 1.38-1.33 (ddd, J=8.6 Hz, 6.1 Hz, 4.9 Hz, 1H). MS (ESI) m/z: Calculated for C20H21N3O2S: 367.14. found: 368.2 (M+H)+.

Provenance & Evidence