3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → N-(2-(2-(4-Fluorophenyl)thiazol-4-yl)-2-methylpropyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

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Reaction Steps

This compound was synthesized from 2-(2-(4-fluorophenyl)thiazol-4-yl)-2-methylpropan-1-amine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (55 mg, yield 30%). 1H NMR (400 MHz, CDCl3) δ 8.53 (m, 1H), 8.26-8.24 (d, J=7.8 Hz, 1H), 8.13-8.11 (m, 1H), 8.07-8.05 (d, J=7.5 Hz, 1H), 7.92-7.89 (m, 2H), 7.62-7.58 (t, J=7.8 Hz, 1H), 7.06-7.02 (m, 3H), 3.71-3.69 (d, J=5.3 Hz, 2H), 1.49 (s, 6H). MS (ESI) m/z: Calculated for C23H18F4N4O2S: 490.11. found: 491.0 (M+H)+.

Provenance & Evidence