3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)aniline → 3-(4-(4-Fluorophenyl)thiazol-2-yl)-N-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)propanamide

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Reaction Steps

This compound was synthesized from 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)aniline and 3-(4-(4-fluorophenyl)thiazol-2-yl)propanoic acid as described in example 8 step 6 (80 mg, yield 43%). 1H NMR (400 MHz, CDCl3) δ 8.80 (br s, 1H), 8.11 (s, 1H), 7.88-7.83 (m, 4H), 7.48-7.44 (t, J=7.9 Hz, 1H), 7.33 (s, 1H), 7.14-7.10 (t, J=8.7 Hz, 2H), 3.52-3.48 (m, 2H), 3.04-3.01 (m, 2H). MS (ESI) m/z: Calculated for C21H14F4N4O2S: 462.08. found: 463.0 (M+H)+.

Provenance & Evidence