2-(4-(4-Fluorophenyl)thiazol-2-yl)ethanamine → N-(2-(4-(4-Fluorophenyl)thiazol-2-yl)ethyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide

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Reaction Steps

This compound was synthesized from 2-(4-(4-fluorophenyl)thiazol-2-yl)ethanamine and 5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid as described in example 8 step 6 (50 mg, yield 29%). 1H NMR (400 MHz, CDCl3) δ 9.45 (d, J=1.3 Hz, 1H), 9.24 (d, J=1.5 Hz, 1H), 8.80 (t, J=2.1 Hz, 1H), 7.86-7.82 (m, 3H), 7.35 (s, 1H), 7.11-7.07 (m, 2H), 4.05-4.00 (q, J=5.7 Hz, 2H), 3.41-3.38 (m, 2H). MS (ESI) m/z: Calculated for C20H13F4N5O2S: 463.07. found: 464.0 (M+H)+.

Provenance & Evidence