3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → HCID 69950026, compound

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Reaction Steps

This compound was synthesized from (4-(3,4-dihydroisoquinolin-2(1H)-yl)tetrahydro-2H-pyran-4-yl)methan amine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (40 mg, yield 30%). 1H NMR (400 MHz, CDCl3) δ 8.45 (s, 1H), 8.22 (d, J=7.8 Hz, 1H), 7.91-7.89 (d, J=7.5 Hz, 1H), 7.59-7.55 (t, J=7.8 Hz, 1H), 7.17-7.15 (m, 3H), 7.12-7.07 (m, 2H), 3.96-3.93 (m, 4H), 3.86-3.85 (d, J=4.8 Hz, 2H), 3.74-3.68 (m, 2H), 2.95 (m, 4H), 2.15-2.07 (m, 2H), 1.58-1.55 (m, 2H). MS (ESI) m/z: Calculated for C25H25F3N4O3: 486.19. found: 487.2 (M+H)+.

Provenance & Evidence