5-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid → N-(2-Methyl-2-(3-phenyl-1H-1,2,4-triazol-5-yl)propyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide

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Reaction Steps

This compound was synthesized from 2-methyl-2-(3-phenyl-1H-1,2,4-triazol-5-yl)propan-1-amine and 5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid as described in example 8 step 6 (20 mg, yield 23%). 1H NMR (400 MHz, MeOD) δ 9.37 (m, 1H), 9.16 (m, 1H), 8.84-8.13 (m, 1H), 8.02-7.99 (m, 2H), 7.48-7.42 (m, 3H), 3.77 (s, 2H), 1.54 (m, 6H). MS (ESI) m/z: Calculated for C21H18F3N7O2: 457.15. found: 458.2 (M+H)+.

Provenance & Evidence