Phosphorus sulfide (P2S5) → Methyl 4-amino-4-thioxobutanoate

Participants

Reaction Steps

A solution of methyl succinamate (2.5 g, 0.019 mol) in THF (60 mL) was cooled to 0° C. and P2S5 (4.2 g, 0.019 mol) was added. The reaction mixture was warmed to room temperature and stirred for 6 h. The solvent was removed under reduced pressure and the crude product was purified by column chromatography (silica gel 60-120 mesh, eluent 35-40% EtOAc in petroleum ether) to afford methyl 4-amino-4-thioxobutanoate (1.6 g, yield 57%). 1H NMR (300 MHz, CDCl3) δ 7.49 (br s, 2H), 3.72 (s, 3H), 2.95-2.86 (m, 4H). MS (ESI) m/z: Calculated for C5H9NO2S: 147.04. found: 248.2 (M+H)+.

Provenance & Evidence