HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18071420, compound → HCID 67344841, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18071420 | HCID 18071420 | — |
| Reactant | 5-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid | HCID 67324216 | — |
| Product | HCID 67344841 | HCID 67344841 | 46% |
Reaction Steps
This compound was synthesized from 2-(2-(4-fluorophenyl)oxazol-4-yl)ethanamine and 5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid as described in example 8 step 6 (55 mg, yield 46%). 1H NMR (400 MHz, MeOD) δ 9.39 (d, J=2.0 Hz, 1H), 9.19 (d, J=2.0 Hz, 1H), 8.89 (t, J=2.0 Hz, 1H), 8.07-8.03 (m, 2H), 7.81 (s, 1H), 7.26-7.22 (m, 2H), 3.78-3.75 (t, J=6.9 Hz, 2H), 2.97-2.94 (t, J=6.9 Hz, 2H). MS (ESI) m/z: Calculated for C20H13F4N5O3: 447.10. found: 448.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901156B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-635a1004c63642318b7b842ec6d75399 |
| Source note | uspto-grants-2014_12 |