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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1397339Generated: October 30, 2026

HCID 18071420, compound → HCID 67344841, compound

https://huagongshe.com/reaction/1397339

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 18071420HCID 18071420—
Reactant5-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acidHCID 67324216—
ProductHCID 67344841HCID 6734484146%

Reaction Steps

This compound was synthesized from 2-(2-(4-fluorophenyl)oxazol-4-yl)ethanamine and 5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid as described in example 8 step 6 (55 mg, yield 46%). 1H NMR (400 MHz, MeOD) δ 9.39 (d, J=2.0 Hz, 1H), 9.19 (d, J=2.0 Hz, 1H), 8.89 (t, J=2.0 Hz, 1H), 8.07-8.03 (m, 2H), 7.81 (s, 1H), 7.26-7.22 (m, 2H), 3.78-3.75 (t, J=6.9 Hz, 2H), 2.97-2.94 (t, J=6.9 Hz, 2H). MS (ESI) m/z: Calculated for C20H13F4N5O3: 447.10. found: 448.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08901156B2
Source datasetuspto-grants-2014_12
ORD IDord-635a1004c63642318b7b842ec6d75399
Source noteuspto-grants-2014_12