3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → HCID 67347057, compound

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Reaction Steps

This compound was synthesized from 2-(2-(4-fluorophenyl)oxazol-4-yl)propan-1-amine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (95 mg, yield 36%) as a yellow solid. 1H NMR (400 MHz, CDCl3) δ 8.59-8.58 (t, J=1.5 Hz, 1H), 8.28-8.26 (dt, J=7.8 Hz, 1.3 Hz, 1H), 8.17-8.14 (dt, J=7.8 Hz, 1.4 Hz, 1H), 8.09-8.05 (m, 2H), 7.90 (m, 1H), 7.67-7.63 (t, J=7.8 Hz, 1H), 7.53 (d, J=0.8 Hz, 1H), 7.14-7.10 (m, 2H), 3.99-3.93 (ddd, J=13.2 Hz, 6.4 Hz, 4.3 Hz, 1H), 3.53-3.46 (ddd, J=13.2 Hz, 8.8 Hz, 4.3 Hz, 1H), 3.19-3.12 (m, 1H), 1.41-1.39 (d, J=7.0 Hz, 3H). MS (ESI) m/z: Calculated for C22H16F4N4O3: 460.12. found: 461.1 (M+H)+.

Provenance & Evidence