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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1397348Generated: October 30, 2026

HCID 67324088, compound → HCID 67346988, compound

https://huagongshe.com/reaction/1397348

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 67324088HCID 67324088—
Reactant5-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acidHCID 67324216—
ProductHCID 67346988HCID 673469889%

Reaction Steps

This compound was synthesized from 2-(2-(3-fluorophenyl)oxazol-4-yl)ethanamine and 5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid as described in example 8 step 6 (15 mg, yield 9%). 1H NMR (400 MHz, MeOD) δ 9.39 (d, J=2.0 Hz, 1H), 9.19 (d, J=2.3 Hz, 1H), 8.90-8.88 (t, J=2.1 Hz, 1H), 7.84-7.82 (m, 2H), 7.72-7.69 (m, 1H), 7.54-7.49 (m, 1H), 7.26-7.21 (m, 1H), 3.79-3.76 (t, J=6.9 Hz, 2H), 2.98-2.95 (t, J=6.9 Hz, 2H). MS (ESI) m/z: Calculated for C20H13F4N5O3: 447.10. found: 448.0 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08901156B2
Source datasetuspto-grants-2014_12
ORD IDord-6a0cf9327a0d4506bd17f05d9c2d87aa
Source noteuspto-grants-2014_12