HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67324088, compound → HCID 67346988, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67324088 | HCID 67324088 | — |
| Reactant | 5-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid | HCID 67324216 | — |
| Product | HCID 67346988 | HCID 67346988 | 9% |
Reaction Steps
This compound was synthesized from 2-(2-(3-fluorophenyl)oxazol-4-yl)ethanamine and 5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid as described in example 8 step 6 (15 mg, yield 9%). 1H NMR (400 MHz, MeOD) δ 9.39 (d, J=2.0 Hz, 1H), 9.19 (d, J=2.3 Hz, 1H), 8.90-8.88 (t, J=2.1 Hz, 1H), 7.84-7.82 (m, 2H), 7.72-7.69 (m, 1H), 7.54-7.49 (m, 1H), 7.26-7.21 (m, 1H), 3.79-3.76 (t, J=6.9 Hz, 2H), 2.98-2.95 (t, J=6.9 Hz, 2H). MS (ESI) m/z: Calculated for C20H13F4N5O3: 447.10. found: 448.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901156B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-6a0cf9327a0d4506bd17f05d9c2d87aa |
| Source note | uspto-grants-2014_12 |