5-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid → HCID 69950184, compound

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Reaction Steps

This compound was synthesized from (4-([1,1′-biphenyl]-3-yl)tetrahydro-2H-pyran-4-yl)methanamine and 5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid as described in example 8 step 6 (95 mg, yield 48%) as a white solid. 1H NMR (400 MHz, CDCl3) δ 9.40 (br s, 1H), 8.97 (br s, 1H), 8.61-8.60 (t, J=1.9 Hz, 1H), 7.58-7.55 (m, 5H), 7.46-7.43 (t, J=7.5 Hz, 2H), 7.39-7.35 (m, 2H), 5.89-5.86 (t, J=6.1 Hz, 1H), 3.96-3.92 (m, 2H), 3.82-3.81 (d, J=6.1 Hz, 2H), 3.74-3.68 (m, 2H), 2.29-2.23 (m, 2H), 2.09-2.03 (m, 2H). MS (ESI) m/z: Calculated for C27H23F3N4O3: 508.17. found: 507.2 (M−H)−.

Provenance & Evidence