2-(2-(4-Fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amine → N-(2-(2-(4-Fluorophenyl)oxazol-4-yl)-2-methylpropyl)-5-(5-(2,2,2-trifluoroacetyl)thiophen-2-yl)nicotinamide

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Reaction Steps

This compound was synthesized from 2-(2-(4-fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amine and 5-(5-(2,2,2-trifluoroacetyl)thiophen-2-yl)nicotinic acid as described in example 8 step 6 (45 mg, yield 26%). 1H NMR (400 MHz, DMSO-d6) δ 9.21 (d, J=2.1 Hz, 1H), 9.01 (s, 1H), 8.66-8.60 (m, 1H), 8.52-8.51 (t, J=2.0 Hz, 1H), 8.21-8.20 (m, 1H), 8.02-7.98 (m, 4H), 7.36-7.30 (m, 2H), 3.53-3.52 (d, J=6.1 Hz, 2H), 1.30 (s, 6H).

Provenance & Evidence