5-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid → HCID 67324923, compound

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Reaction Steps

This compound was synthesized from 2-(1-methyl-2-phenyl-1H-imidazol-5-yl)propan-1-amine and 5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid as described in example 8 step 6 (35 mg, yield 28%). 1H NMR (400 MHz, DMSO-d6) δ 9.36 (d, J=2.1 Hz, 1H), 9.28-9.26 (m, 2H), 8.84-8.83 (t, J=2.0 Hz, 1H), 7.65-7.63 (m, 2H), 7.50-7.42 (m, 4H), 6.92 (s, 1H), 3.70 (s, 3H), 3.66-3.61 (m, 1H), 3.32-3.28 (m, 1H), 3.22-3.17 (m, 1H), 1.33-1.32 (d, J=6.7 Hz, 3H). MS (ESI) m/z: Calculated for C22H19F3N6O2: 456.15. found: 457.2 (M+H)+.

Provenance & Evidence