3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → N-(2-(2-(4-Fluorophenyl)oxazol-4-yl)-2-hydroxyethyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

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Reaction Steps

This compound was synthesized from 2-amino-1-(2-(4-fluorophenyl)oxazol-4-yl)ethanol and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (70 mg, yield 39%). 1H NMR (400 MHz, CDCl3) δ 8.51 (m, 1H), 8.28-8.26 (m, 1H), 8.08-8.01 (m, 3H), 7.73 (s, 1H), 7.66-7.62 (m, 1H), 7.17-7.08 (m, 3H), 5.05-5.03 (m, 1H), 4.12-4.06 (ddd, J=14.1 Hz, 6.3 Hz, 3.8 Hz, 1H), 3.91-3.85 (m, 1H), 3.77 (br s, 1H). MS (ESI) m/z: Calculated for C21H14F4N4O4: 462.10. found: 463.1 (M+H)+.

Provenance & Evidence