3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → HCID 53345358, compound

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Reaction Steps

This compound was synthesized from (4-(2-(4-chlorophenyl)oxazol-4-yl)-1-methylpiperidin-4-yl)methanamine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 96 step 3 (12 mg, yield 5%). 1H NMR (400 MHz, CDCl3) [free amine] δ 8.56 (s, 1H), 8.28-8.26 (d, J=7.7 Hz, 1H), 8.13-8.11 (d, J=7.6 Hz, 1H), 8.02-8.00 (d, J=8.5 Hz, 2H), 7.79-7.75 (m, 1H), 7.66-7.62 (d, J=7.2 Hz, 1H), 7.57 (s, 1H), 7.42-7.40 (d, J=8.2 Hz, 2H), 3.77-3.76 (d, J=4.7 Hz, 2H), 2.79-2.77 (m, 2H), 2.59 (m, 2H), 2.42 (m, 3H), 2.22-2.21 (m, 2H), 2.08-2.04 (m, 2H). MS (ESI) m/z: Calculated for C26H23ClF3N5O3: 545.14. found: 546.2 (M+H)+.

Provenance & Evidence