2-Chloro-5-cyanobenzoic acid → 2-Chloro-5-cyano-N-(2-(2-(4-fluorophenyl)oxazol-4-yl)-2-methylpropyl)benzamide

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Reaction Steps

This compound was synthesized from 2-(2-(4-fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amine and 2-chloro-5-cyanobenzoic acid as described in example 8 step 6 (300 mg, yield 44%). 1H NMR (400 MHz, CDCl3) δ 8.02 (d, J=2.0 Hz, 1H), 7.98-7.95 (m, 2H), 7.66-7.63 (m, 1H), 7.56-7.54 (d, J=8.3 Hz, 1H), 7.48 (s, 1H), 7.39 (m, 1H), 7.17-7.13 (t, J=8.8 Hz, 2H), 3.68-3.66 (d, J=5.8 Hz, 2H), 1.41 (s, 6H). MS (ESI) m/z: Calculated for C21H17ClFN3O2: 397.10. found: 396.4 (M−H)−.

Provenance & Evidence