2-(2-(4-Fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amine → HCID 67323785, compound

HRID 1397430Notes

Reaction equation

HRID 1397430 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[C:11]([C:13]([CH3:17])([CH3:16])[CH2:14][NH2:15])[N:12]=2)=[CH:4][CH:3]=1.[F:18][C:19]([F:37])([F:36])[C:20]([C:22]1[S:26][C:25]([C:27]2[CH:28]=[C:29]([CH:33]=[CH:34][CH:35]=2)[C:30](O)=[O:31])=[N:24][CH:23]=1)=[O:21]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][CH:10]=[C:11]([C:13]([CH3:17])([CH3:16])[CH2:14][NH:15][C:30](=[O:31])[C:29]3[CH:33]=[CH:34][CH:35]=[C:27]([C:25]4[S:26][C:22]([C:20](=[O:21])[C:19]([F:37])([F:18])[F:36])=[CH:23][N:24]=4)[CH:28]=3)[N:12]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 673230862-(2-(4-Fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amineHCID 67324127HCID 67324127, compound

Product 1

HCID 67323785HCID 67323785, compoundYield 3%

Procedure

This compound was synthesized from 2-(2-(4-fluorophenyl)oxazol-4-yl)-2-methylpropan-1-amine and 3-(5-(2,2,2-trifluoroacetyl)thiazol-2-yl)benzoic acid as described in example 8 step 6 (7 mg, yield 3%). 1H NMR (400 MHz, DMSO-d6) δ 8.56-8.53 (t, J=5.5 Hz, 1H), 8.35 (m, 1H), 8.28 (m, 2H), 8.10-8.08 (m, 1H), 8.02-8.00 (m, 2H), 7.94 (m, 1H), 7.61-7.57 (t, J=7.8 Hz, 1H), 7.35-7.31 (t, J=8.7 Hz, 2H), 3.51-3.50 (d, J=5.8 Hz, 2H), 1.29 (s, 6H). MS (ESI) m/z: Calculated for C26H19F4N3O3S: 517.11. found: 516.1 (M−H)−.

Sources & evidence

ORD record
ord-fcbb348b14ae4a578ed54d88c762bb25
Source dataset
uspto-grants-2014_12
Patent number
US08901156B2

Reaction notes

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