3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → HCID 69949424, compound

Participants

Reaction Steps

This compound was synthesized from 2-(2-(4-fluorophenyl)oxazol-4-yl)-2-methoxyethanamine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (44 mg, yield 22%) as an off-white solid. 1H NMR (400 MHz, CDCl3) δ 8.56-8.55 (t, J=1.6 Hz, 1H), 8.29-8.26 (dt, J=7.9 Hz, 1.3 Hz, 1H), 8.11-8.06 (m, 3H), 7.73 (s, 1H), 7.67-7.63 (t, J=7.7 Hz, 1H), 7.22-7.19 (m, 1H), 7.17-7.13 (t, J=8.7 Hz, 2H), 4.54-4.51 (dd, J=5.9 Hz, 5.1 Hz, 1H), 4.12-4.06 (ddd, J=13.9 Hz, 6.5 Hz, 4.9 Hz, 1H), 3.87-3.81 (ddd, J=13.9 Hz, 6.1 Hz, 4.8 Hz, 1H), 3.45 (s, 3H). MS (ESI) m/z: Calculated for C22H16F4N4O4: 476.11. found: 475.6 (M)−.

Provenance & Evidence