Methyl iodide → 2-(4-(4-Fluorophenyl)thiazol-2-yl)propanenitrile

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2-(4-(4-fluorophenyl)thiazol-2-yl)acetonitrile (500 mg, 2.29 mmol) in THF (10 mL) at −78° C. was added LiHMDS (1M in THF; 2.06 mL, 2.06 mmol) and the reaction mixture was stirred at −78° C. for 10 min. Iodomethane (0.12 mL, 2.06 mmol) in THF (2 mL) was then added dropwise and the reaction mixture was stirred at −78° C. for 30 min. The reaction mixture was diluted with EtOAc, washed with saturated aqueous NH4Cl solution, water, brine, and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to give the crude product; which was purified on a Teledyne ISCO automated column chromatography system (0-30% EtOAc/Hexanes) to give 2-(4-(4-fluorophenyl)thiazol-2-yl)propanenitrile (180 mg, yield 34%). MS (ESI) m/z: Calculated for C12H9FN2S: 232.05. found: 233.1 (M+H)

Provenance & Evidence