3-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid → N-(2-(3-Bromophenyl)-2-methylpropyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

HRID 1397443Notes

Reaction equation

HRID 1397443 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([CH3:12])([CH3:11])[CH2:9][NH2:10])[CH:5]=[CH:6][CH:7]=1.[F:13][C:14]([F:30])([F:29])[C:15]1[O:19][N:18]=[C:17]([C:20]2[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=2)[C:23](O)=[O:24])[N:16]=1>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([CH3:12])([CH3:11])[CH2:9][NH:10][C:23](=[O:24])[C:22]2[CH:26]=[CH:27][CH:28]=[C:20]([C:17]3[N:16]=[C:15]([C:14]([F:30])([F:29])[F:13])[O:19][N:18]=3)[CH:21]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 251808543-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acidHCID 470031873-Bromo-beta,beta-dimethylbenzeneethanamine

Product 1

HCID 69950294N-(2-(3-Bromophenyl)-2-methylpropyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamideYield 83%

Procedure

This compound was synthesized from 2-(3-bromophenyl)-2-methylpropan-1-amine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (90 mg, yield 83%). MS (ESI) m/z: Calculated for C20H17BrF3N3O2: 467.05. found: 468.0 (M+H)+.

Sources & evidence

ORD record
ord-e19a7568c5bf467ab3eef8fdc0d73902
Source dataset
uspto-grants-2014_12
Patent number
US08901156B2

Reaction notes

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