Bis(2-bromoethyl) ether → HCID 67323723, compound

HRID 1397445Notes

Reaction equation

HRID 1397445 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([CH2:14][C:15]#[N:16])[S:12][CH:13]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.Br[CH2:18][CH2:19][O:20][CH2:21][CH2:22]Br>>[F:8][C:6]1[CH:5]=[C:4]([C:9]2[N:10]=[C:11]([C:14]3([C:15]#[N:16])[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[S:12][CH:13]=2)[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 21521Bis(2-bromoethyl) etherHCID 67323855HCID 67323855, compound

Product 1

HCID 67323723HCID 67323723, compoundYield 59%

Procedure

This compound was synthesized from 2-(4-(3,5-difluorophenyl)thiazol-2-yl)acetonitrile using 2-bromoethyl ether as described in example 1 step 2 (1.0 g, yield 59%). MS (ESI) m/z: Calculated for C15H12F2N2OS: 306.06. found: 307.1 (M+H)+.

Sources & evidence

ORD record
ord-3943c3cd8274427b8c5882c50640f2fc
Source dataset
uspto-grants-2014_12
Patent number
US08901156B2

Reaction notes

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