3-Cyanobenzoic acid → HCID 67326054, compound

HRID 1397471Notes

Reaction equation

[C:1]1([C:7]2[N:8]=[C:9]([C:12]3([CH2:18][NH2:19])[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20]([C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25](O)=[O:26])#[N:21]>>[C:20]([C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25]([NH:19][CH2:18][C:12]1([C:9]2[S:10][CH:11]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[N:8]=2)[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1)=[O:26])#[N:21]

Participants

Reactant 2

HCID 158753-Cyanobenzoic acid

HCID 67322930(4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine

Product 1

HCID 67326054HCID 67326054, compoundYield 89%

Procedure

This compound was synthesized from (4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine and 3-cyanobenzoic acid as described in example 8 step 6 (6.6 g, yield 89%) as a white solid. 1H NMR (300 MHz, CDCl3) δ 8.11-8.10 (m, 1H), 8.02-7.99 (dt, J=7.9 Hz, 1.5 Hz, 1H), 7.91-7.88 (m, 2H), 7.78-7.74 (dt, J=7.7 Hz, 1.3 Hz, 1H), 7.71-7.68 (m, 1H), 7.53-7.46 (m, 3H), 7.42-7.36 (m, 1H), 3.97-3.90 (m, 2H), 3.85-3.83 (d, J=5.7 Hz, 2H), 3.77-3.69 (m, 2H), 2.35-2.29 (m, 2H), 2.07-1.98 (m, 2H). MS (ESI) m/z: Calculated for C23H21N3O2S: 403.14. found: 402.2 (M−H)−.

Sources & evidence

ORD record: ord-936ec704acbb4522847b13ea9b6dfb7c
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08901156B2

Reaction notes

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