Aluminium lithium hydride → (+/-)-1-(4-chloro-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan-2-yl)-N-methylmethanamine

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Reaction Steps

Treatment of (±)-methyl (4-chloro-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan-2-yl)methylcarbamate (0.60 g, 2.12 mmol) with lithium aluminum hydride (95 wt. %, 0.35 g, 8.75 mmol) generally according to the procedure described for Example 24 provided 0.15 g (30%) of (±)-1-(4-chloro-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan-2-yl)-N-methylmethanamine as a white solid. mp 58-60° C.; Anal. calcd. for C13H16ClNO: C, 65.68; H, 6.78; N, 5.89. Found: C, 65.31; H, 6.79; N, 5.52.

Provenance & Evidence