Ammonia → 4,5-Pyrimidinediamine, 6-chloro-

HRID 1397615Notes

Reaction equation

HRID 1397615 reaction equation
[NH2:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[N:6][C:7]=1[Cl:8].[NH3:10]>>[Cl:8][C:7]1[N:6]=[CH:5][N:4]=[C:3]([NH2:10])[C:2]=1[NH2:1]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 794345-Amino-4,6-dichloropyrimidine

Product 1

HCID 780104,5-Pyrimidinediamine, 6-chloro-

Conditions

Temperature
118 °C

Procedure

A suspension of 5-Amino-4,6-dichloropyrimidine (3 g, 0.02 mol) in ammonia (25 mL, 7N/MeOH, 0.175 mole) was heated at 118° C. overnight (under pressure). The reaction was cooled to 23° C., filtered and washed with ethanol to obtain 1.92 g (70%).

Workup

  1. temperatureThe reaction was cooled to 23° C.
  2. filtrationfiltered
  3. washwashed with ethanol
  4. customto obtain 1.92 g (70%)

Sources & evidence

ORD record
ord-cc391b065f0e4e919b76c4fae6cbbaae
Source dataset
uspto-grants-2014_12
Patent number
US08901136B2

Reaction notes

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