HCID 21123040, compound → L-(-)-Fucose

MoO3 (600 mg) was added to a mixture of 6-deoxy-L-talose (100 g) in water (1.5 l). The reaction mixture was stirred for 9.5 h at reflux. At 80° C. resin IRA-67 (SUPELCO, 50 g) was added and the mixture was stirred for further 30 min, filtered and distilled off. The residue was dissolved in isopropanol (400 ml) and directly evaporated. Isobutanol (400 ml) was then added and the mixture was heated under reflux for 10 min and allowed to cool. Crystallization spontaneously occurs or it was promoted by adding seed crystals. After one night at room temperature the suspension was filtered to give L-fucose (52 g, 52%).

1. temperatureat reflux
2. customAt 80° C.
3. addition(SUPELCO, 50 g) was added
4. stirringthe mixture was stirred for further 30 min
5. filtrationfiltered
6. distillationdistilled off
7. dissolutionThe residue was dissolved in isopropanol (400 ml)
8. customdirectly evaporated
9. additionIsobutanol (400 ml) was then added
10. temperaturethe mixture was heated
11. temperatureunder reflux for 10 min
12. temperatureto cool
13. customCrystallization
14. additionby adding seed crystals
15. filtrationAfter one night at room temperature the suspension was filtered

ORD record

ord-391d687b0df3409bb195ec9466b0def5

Source dataset

uspto-grants-2014_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08901291B2