Diisopropylethylamine → HCID 68946820, compound

Participants

Reaction Steps

Prepared according to Procedure H using (8-chloro-2-phenylquinolin-3-yl)meth-anamine (0.050 g, 0.186 mmol), 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (0.034 g, 0.22 mmol, 1.2 eq) and DIEA (0.38 mmol, 2.0 eq) in n-butanol (3 mL). N-((8-chloro-2-phenylquinolin-3-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine [PI3Kδ IC50=270 nM] was obtained after purification as a white solid. 1H-NMR (MeOD) δ ppm 8.65-8.76 (m, 1 H), 8.53 (s, 1 H), 8.11-8.20 (m, 4 H), 8.07 (d, J=1.96 Hz, 1 H), 7.91-8.00 (m, 2 H), 7.86 (s, 1 H), 7.51-7.58 (m, 2 H), 4.73-4.85 (m, 2 H), Mass Spectrum (ESI) m/e=386 (M+1).

Provenance & Evidence