Diisopropylethylamine → HCID 178505772, compound

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Reaction Steps

Prepared according to Procedure H using (8-chloro-2-(2-chloro-5-fluorophenyl)-quinolin-3-yl)methanamine (0.050 g, 0.156 mmol), 6-chloropurine (0.027 g, 0.17 mmol, 1.2 eq) and DIEA (0.70 mmol, 2.0 eq) in n-butanol (3 mL). N-((8-chloro-2-(2-chloro-5-fluorophenyl)quinolin-3-yl)methyl)-9H-purin-6-amine [PI3Kδ IC50=71 nM] was obtained after purification as a white solid. 1H-NMR (MeOD) δ ppm 8.30 (s, 1 H), 8.20 (s, 1 H), 7.80 (dd, J=7.58, 0.49 Hz, 2 H), 7.69-7.75 (m, 1 H), 7.42-7.47 (m, 1 H), 7.31-7.37 (m, 1 H), 7.11-7.16 (m, 1 H), 6.99-7.06 (m, 1 H), 4.90-497. (m, 2 H), Mass Spectrum (ESI) m/e=440 (M+1)

Provenance & Evidence