Diisopropylethylamine → HCID 178461888, compound

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Reaction Steps

Prepared according to Procedure H using (1S)-1-(8-chloro-2-(thiazol-4-yl)-quinolin-3-yl)ethanamine (0.045 g, 0.155 mmol), 6-chloropurine (0.029 g, 0.19 mmol, 1.2 eq) and DIEA (0.33 mmol, 2.0 eq) in n-butanol (3 mL). N—((S)-1-(8-chloro-2-(thiazol-4-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine [PI3Kδ IC50=16 nM] was obtained after purification as a white solid. 1H-NMR (MeOD) δ ppm 9.22 (s, 1 H), 8.63 (s, 1 H), 8.44-8.46 (m, 1 H), 8.42 (s, 1 H), 8.34 (s, 1 H), 7.88-7.93 (m, 2 H), 7.56 (t, 1 H), 1.77 (d, 3H), Mass Spectrum (ESI) m/e=408 (M+1).

Provenance & Evidence